Carbamic acid, ethyl ester → HCID 71252738, compound

HRID 2411826Notes

Reaction equation

HRID 2411826 reaction equation
[CH:1]1([C:4]2[C:5]([N:13]3[CH2:18][CH2:17][N:16]([C:19]([C:21]4[CH:26]=[CH:25][C:24](I)=[CH:23][CH:22]=4)=[O:20])[CH2:15][CH2:14]3)=[N:6][CH:7]=[C:8]([CH:10]3[CH2:12][CH2:11]3)[CH:9]=2)[CH2:3][CH2:2]1.[CH2:28]([O:30][C:31](=[O:33])[NH2:32])[CH3:29]>>[CH2:28]([O:30][C:31](=[O:33])[NH:32][C:24]1[CH:25]=[CH:26][C:21]([C:19]([N:16]2[CH2:15][CH2:14][N:13]([C:5]3[C:4]([CH:1]4[CH2:3][CH2:2]4)=[CH:9][C:8]([CH:10]4[CH2:11][CH2:12]4)=[CH:7][N:6]=3)[CH2:18][CH2:17]2)=[O:20])=[CH:22][CH:23]=1)[CH3:29]

Participants

3

Reactant 2

HCID 5641Carbamic acid, ethyl esterHCID 58484688[4-(3,5-Dicyclopropylpyridin-2-yl)piperazin-1-yl](4-iodophenyl)methanone

Product 1

HCID 71252738HCID 71252738, compoundYield 48.1%

Procedure

Using [4-(3,5-dicyclopropylpyridin-2-yl)piperazin-1-yl](4-iodophenyl)methanone (473 mg) described in Preparation Example 186 and carbamic acid ethyl ester (137 mg) and by the reaction and treatment in the same manner as in Example 262, the title compound (209 mg) was obtained.

Sources & evidence

ORD record
ord-e0a7b590f5d44647b9dd5e8ab94aaaaa
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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