Methyl Carbamate → HCID 71253001, compound

HRID 2411827Notes

Reaction equation

HRID 2411827 reaction equation
[CH:1]1([C:4]2[C:5]([N:13]3[CH2:18][CH2:17][N:16]([C:19]([C:21]4[CH:26]=[CH:25][C:24](I)=[CH:23][CH:22]=4)=[O:20])[CH2:15][CH2:14]3)=[N:6][CH:7]=[C:8]([CH:10]3[CH2:12][CH2:11]3)[CH:9]=2)[CH2:3][CH2:2]1.[CH3:28][O:29][C:30](=[O:32])[NH2:31]>>[CH3:28][O:29][C:30](=[O:32])[NH:31][C:24]1[CH:23]=[CH:22][C:21]([C:19]([N:16]2[CH2:15][CH2:14][N:13]([C:5]3[C:4]([CH:1]4[CH2:2][CH2:3]4)=[CH:9][C:8]([CH:10]4[CH2:12][CH2:11]4)=[CH:7][N:6]=3)[CH2:18][CH2:17]2)=[O:20])=[CH:26][CH:25]=1

Participants

3

Reactant 2

HCID 11722Methyl CarbamateHCID 58484688[4-(3,5-Dicyclopropylpyridin-2-yl)piperazin-1-yl](4-iodophenyl)methanone

Product 1

HCID 71253001HCID 71253001, compoundYield 38.3%

Procedure

Using [4-(3,5-dicyclopropylpyridin-2-yl)piperazin-1-yl](4-iodophenyl)methanone (473 mg) described in Preparation Example 186 and carbamic acid methyl ester (113 mg) and by the reaction and treatment in the same manner as in Example 262, the title compound (161 mg) was obtained.

Sources & evidence

ORD record
ord-eb62e1e9324c4b059a52c520c75db483
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

Loading…