Carbamic acid, N-methyl-, ethyl ester → HCID 71253047, compound

HRID 2411828Notes

Reaction equation

HRID 2411828 reaction equation
[CH:1]1([C:4]2[C:5]([N:13]3[CH2:18][CH2:17][N:16]([C:19]([C:21]4[CH:26]=[CH:25][C:24](I)=[CH:23][CH:22]=4)=[O:20])[CH2:15][CH2:14]3)=[N:6][CH:7]=[C:8]([CH:10]3[CH2:12][CH2:11]3)[CH:9]=2)[CH2:3][CH2:2]1.[CH2:28]([O:30][C:31](=[O:34])[NH:32][CH3:33])[CH3:29]>>[CH2:28]([O:30][C:31](=[O:34])[NH:32][CH2:33][C:24]1[CH:25]=[CH:26][C:21]([C:19]([N:16]2[CH2:17][CH2:18][N:13]([C:5]3[C:4]([CH:1]4[CH2:3][CH2:2]4)=[CH:9][C:8]([CH:10]4[CH2:11][CH2:12]4)=[CH:7][N:6]=3)[CH2:14][CH2:15]2)=[O:20])=[CH:22][CH:23]=1)[CH3:29]

Participants

3

Reactant 2

HCID 7752Carbamic acid, N-methyl-, ethyl esterHCID 58484688[4-(3,5-Dicyclopropylpyridin-2-yl)piperazin-1-yl](4-iodophenyl)methanone

Product 1

HCID 71253047HCID 71253047, compound

Procedure

Using [4-(3,5-dicyclopropylpyridin-2-yl)piperazin-1-yl](4-iodophenyl)methanone (473 mg) described in Preparation Example 186 and methylcarbamic acid ethyl ester (152 μL) and by the reaction and treatment in the same manner as in Example 262, the title compound (203 mg) was obtained.

Sources & evidence

ORD record
ord-b1c02bc8228740b6a3b60b5139f0ce76
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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