1-(5-Cyclopropyl-3-methylpyridin-2-yl)piperazine → (1-{4-[4-(3,5-Dimethylpyridin-2-yl)piperazine-1-carbonyl]phenyl}-1-methylethyl)carbamic acid ethyl ester

Participants

Reaction Steps

Using methyl 4-(1-ethoxycarbonylamino-1-methylethyl)benzoate (174 mg) described in Preparation Example 70 and 1-(5-cyclopropyl-3-methylpyridin-2-yl)piperazine (157 mg) described in Preparation Example 83 and by the reaction and treatment in the same manner as in Example 109, the title compound (235 mg) was obtained.

Provenance & Evidence