4-(Methylsulfonamido)benzoic acid → HCID 71252312, compound

HRID 2411839Notes

Reaction equation

HRID 2411839 reaction equation
[CH3:1][S:2]([NH:5][C:6]1[CH:14]=[CH:13][C:9]([C:10]([OH:12])=O)=[CH:8][CH:7]=1)(=[O:4])=[O:3].Cl.[Cl:16][C:17]1[CH:22]=[CH:21][C:20]([C:23]([CH:25]2[CH2:30][CH2:29][NH:28][CH2:27][CH2:26]2)=[O:24])=[CH:19][CH:18]=1>>[Cl:16][C:17]1[CH:18]=[CH:19][C:20]([C:23]([CH:25]2[CH2:30][CH2:29][N:28]([C:10]([C:9]3[CH:8]=[CH:7][C:6]([NH:5][S:2]([CH3:1])(=[O:3])=[O:4])=[CH:14][CH:13]=3)=[O:12])[CH2:27][CH2:26]2)=[O:24])=[CH:21][CH:22]=1

Participants

3

Reactant 2

HCID 2506534-(Methylsulfonamido)benzoic acidHCID 27771144-(4-Chlorobenzoyl)piperidine hydrochloride

Product 1

HCID 71252312HCID 71252312, compoundYield 53.9%

Procedure

Using 4-methanesulfonylaminobenzoic acid (800 mg) and (4-chlorophenyl)(piperidin-4-yl)methanone hydrochloride (967 mg) and by the reaction and treatment in the same manner as in Example 86, the title compound (843 mg) was obtained.

Workup

  1. customby the reaction and treatment in the same manner as in Example 86

Sources & evidence

ORD record
ord-b5642ae623474aed9923b33228b7252c
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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