4-{[(Methylsulfonyl)amino]methyl}benzoic acid → N-{4-[4-(4-chlorobenzoyl)piperidine-1-carbonyl]benzyl}methanesulfonamide

HRID 2411840Notes

Reaction equation

HRID 2411840 reaction equation
[CH3:1][S:2]([NH:5][CH2:6][C:7]1[CH:15]=[CH:14][C:10]([C:11]([OH:13])=O)=[CH:9][CH:8]=1)(=[O:4])=[O:3].Cl.[Cl:17][C:18]1[CH:23]=[CH:22][C:21]([C:24]([CH:26]2[CH2:31][CH2:30][NH:29][CH2:28][CH2:27]2)=[O:25])=[CH:20][CH:19]=1>>[Cl:17][C:18]1[CH:19]=[CH:20][C:21]([C:24]([CH:26]2[CH2:31][CH2:30][N:29]([C:11]([C:10]3[CH:9]=[CH:8][C:7]([CH2:6][NH:5][S:2]([CH3:1])(=[O:3])=[O:4])=[CH:15][CH:14]=3)=[O:13])[CH2:28][CH2:27]2)=[O:25])=[CH:22][CH:23]=1

Participants

3

Reactant 2

HCID 15066094-{[(Methylsulfonyl)amino]methyl}benzoic acidHCID 27771144-(4-Chlorobenzoyl)piperidine hydrochloride

Product 1

HCID 71251914N-{4-[4-(4-chlorobenzoyl)piperidine-1-carbonyl]benzyl}methanesulfonamideYield 54.5%

Procedure

Using 4-(methanesulfonylaminomethyl)benzoic acid (100 mg) and (4-chlorophenyl)(piperidin-4-yl)methanone hydrochloride (113 mg) and by the reaction and treatment in the same manner as in Example 86, the title compound (103 mg) was obtained.

Workup

  1. customby the reaction and treatment in the same manner as in Example 86

Sources & evidence

ORD record
ord-da83c04e8efb4a1faa563d1129269947
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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