HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-{[(Methylsulfonyl)amino]methyl}benzoic acid → N-{4-[4-(4-methylbenzoyl)piperidine-1-carbonyl]benzyl}methanesulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-{[(Methylsulfonyl)amino]methyl}benzoic acid | HCID 1506609 | — |
| Reactant | 4-(4-Methylbenzoyl)piperidine hydrochloride | HCID 2740817 | — |
| Product | N-{4-[4-(4-methylbenzoyl)piperidine-1-carbonyl]benzyl}methanesulfonamide | HCID 71252254 | 32% |
Reaction Steps
Using 4-(methanesulfonylaminomethyl)benzoic acid (145 mg) and (4-methylphenyl)(piperidin-4-yl)methanone hydrochloride (152 mg) and by the reaction and treatment in the same manner as in Example 86, the title compound (84 mg) was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08816079B2 |
| Source dataset | uspto-grants-2014_08 |
| ORD ID | ord-e51f219fc99e4f6eabb2550c5ec1e4a5 |
| Source note | uspto-grants-2014_08 |