p-Acetamidobenzoic acid → HCID 71251888, compound

HRID 2411844Notes

Reaction equation

HRID 2411844 reaction equation
[C:1]([NH:4][C:5]1[CH:13]=[CH:12][C:8]([C:9]([OH:11])=O)=[CH:7][CH:6]=1)(=[O:3])[CH3:2].[CH3:14][C:15]1[CH:20]=[C:19]([CH3:21])[CH:18]=[CH:17][C:16]=1[N:22]1[CH2:27][CH2:26][NH:25][CH2:24][CH2:23]1>>[CH3:14][C:15]1[CH:20]=[C:19]([CH3:21])[CH:18]=[CH:17][C:16]=1[N:22]1[CH2:23][CH2:24][N:25]([C:9]([C:8]2[CH:7]=[CH:6][C:5]([NH:4][C:1](=[O:3])[CH3:2])=[CH:13][CH:12]=2)=[O:11])[CH2:26][CH2:27]1

Participants

3

Reactant 2

HCID 19266p-Acetamidobenzoic acidHCID 705441-(2,4-Xylyl)piperazine

Product 1

HCID 71251888HCID 71251888, compoundYield 99.7%

Procedure

Using 4-(acetylamino)benzoic acid (179 mg) and 1-(2,4-dimethylphenyl)piperazine (190 mg) and by the reaction and treatment in the same manner as in Example 93, the title compound (350 mg) was obtained.

Workup

  1. customby the reaction and treatment in the same manner as in Example 93

Sources & evidence

ORD record
ord-f24a02449354447c80d791960bfd6151
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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