4-(4-Methoxybenzoyl)piperidine hydrochloride → HCID 71252420, compound

HRID 2411845Notes

Reaction equation

HRID 2411845 reaction equation
[N:1]1[C:9]2[C:4](=[N:5][CH:6]=[CH:7][CH:8]=2)[N:3]([C:10]2[CH:20]=[CH:19][C:13]([C:14]([O:16]CC)=O)=[CH:12][CH:11]=2)[CH:2]=1.Cl.[CH3:22][O:23][C:24]1[CH:29]=[CH:28][C:27]([C:30]([CH:32]2[CH2:37][CH2:36][NH:35][CH2:34][CH2:33]2)=[O:31])=[CH:26][CH:25]=1>>[N:1]1[C:9]2[C:4](=[N:5][CH:6]=[CH:7][CH:8]=2)[N:3]([C:10]2[CH:11]=[CH:12][C:13]([C:14]([N:35]3[CH2:36][CH2:37][CH:32]([C:30](=[O:31])[C:27]4[CH:26]=[CH:25][C:24]([O:23][CH3:22])=[CH:29][CH:28]=4)[CH2:33][CH2:34]3)=[O:16])=[CH:19][CH:20]=2)[CH:2]=1

Participants

3

Reactant 2

HCID 27405874-(4-Methoxybenzoyl)piperidine hydrochlorideHCID 71252216Ethyl 4-(imidazo[4,5-b]pyridin-3-yl)benzoate

Product 1

HCID 71252420HCID 71252420, compoundYield 66.6%

Procedure

Using ethyl 4-(imidazo[4,5-b]pyridin-3-yl)benzoate (300 mg) described in Preparation Example 77 and (4-methoxyphenyl)(piperidin-4-yl)methanone hydrochloride (287 mg) and by the reaction and treatment in the same manner as in Example 170, the title compound (329 mg) was obtained.

Sources & evidence

ORD record
ord-e26f232c89f1461d9b82f7307b2b71a6
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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