HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(4-Methylbenzoyl)piperidine hydrochloride → [4-(Imidazo[4,5-b]pyridin-3-yl)phenyl][4-(4-methylbenzoyl)piperidin-1-yl]methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(4-Methylbenzoyl)piperidine hydrochloride | HCID 2740817 | — |
| Reactant | Ethyl 4-(imidazo[4,5-b]pyridin-3-yl)benzoate | HCID 71252216 | — |
| Product | [4-(Imidazo[4,5-b]pyridin-3-yl)phenyl][4-(4-methylbenzoyl)piperidin-1-yl]methanone | HCID 71252104 | 63.9% |
Reaction Steps
Using ethyl 4-(imidazo[4,5-b]pyridin-3-yl)benzoate (300 mg) described in Preparation Example 77 and (4-methylphenyl)(piperidin-4-yl)methanone hydrochloride (269 mg) and by the reaction and treatment in the same manner as in Example 170, the title compound (304.2 mg) was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08816079B2 |
| Source dataset | uspto-grants-2014_08 |
| ORD ID | ord-7921b234519c41a182fc127401732a8c |
| Source note | uspto-grants-2014_08 |