4-(4-Methylbenzoyl)piperidine hydrochloride → HCID 71252360, compound

HRID 2411847Notes

Reaction equation

HRID 2411847 reaction equation
[N:1]1([C:10]2[CH:20]=[CH:19][C:13]([C:14]([O:16]CC)=O)=[CH:12][N:11]=2)[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[CH:2]1.Cl.[CH3:22][C:23]1[CH:28]=[CH:27][C:26]([C:29]([CH:31]2[CH2:36][CH2:35][NH:34][CH2:33][CH2:32]2)=[O:30])=[CH:25][CH:24]=1>>[N:1]1([C:10]2[N:11]=[CH:12][C:13]([C:14]([N:34]3[CH2:35][CH2:36][CH:31]([C:29](=[O:30])[C:26]4[CH:25]=[CH:24][C:23]([CH3:22])=[CH:28][CH:27]=4)[CH2:32][CH2:33]3)=[O:16])=[CH:19][CH:20]=2)[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[CH:2]1

Participants

3

Reactant 2

HCID 27408174-(4-Methylbenzoyl)piperidine hydrochlorideHCID 36355606HCID 36355606, compound

Product 1

HCID 71252360HCID 71252360, compoundYield 45.6%

Procedure

Using ethyl 6-(benzimidazol-1-yl)nicotinate (300 mg) described in Preparation Example 78, (4-methylphenyl)(piperidin-4-yl)methanone hydrochloride (269 mg) and by the reaction and treatment in the same manner as in Example 170, the title compound (217 mg) was obtained.

Sources & evidence

ORD record
ord-04291e446e5140c5b33e3ad22d21a566
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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