1-(2,4-Xylyl)piperazine → HCID 71251911, compound

HRID 2411848Notes

Reaction equation

HRID 2411848 reaction equation
[N:1]1([C:10]2[CH:19]=[CH:18][C:13]([C:14]([O:16]C)=O)=[CH:12][CH:11]=2)[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[CH:2]1.[CH3:20][C:21]1[CH:26]=[C:25]([CH3:27])[CH:24]=[CH:23][C:22]=1[N:28]1[CH2:33][CH2:32][NH:31][CH2:30][CH2:29]1>>[N:1]1([C:10]2[CH:11]=[CH:12][C:13]([C:14]([N:31]3[CH2:32][CH2:33][N:28]([C:22]4[CH:23]=[CH:24][C:25]([CH3:27])=[CH:26][C:21]=4[CH3:20])[CH2:29][CH2:30]3)=[O:16])=[CH:18][CH:19]=2)[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[CH:2]1

Participants

3

Reactant 2

HCID 705441-(2,4-Xylyl)piperazineHCID 5328451HCID 5328451, compound

Product 1

HCID 71251911HCID 71251911, compoundYield 55.6%

Procedure

Using methyl 4-(benzimidazol-1-yl)benzoate (126 mg) and 1-(2,4-dimethylphenyl)piperazine (95 mg) and by the reaction and treatment in the same manner as in Example 109, the title compound (114 mg) was obtained.

Workup

  1. customby the reaction and treatment in the same manner as in Example 109

Sources & evidence

ORD record
ord-9a6350d9ad7a438cab56df856760c36c
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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