1-(3,5-Dimethylpyridin-2-yl)piperazine → HCID 71252065, compound

HRID 2411852Notes

Reaction equation

HRID 2411852 reaction equation
[O:1]=[S:2]1(=[O:19])[CH2:6][CH2:5][CH2:4][N:3]1[CH2:7][C:8]1[CH:17]=[CH:16][C:11]([C:12]([O:14]C)=O)=[C:10]([F:18])[CH:9]=1.[CH3:20][C:21]1[C:22]([N:28]2[CH2:33][CH2:32][NH:31][CH2:30][CH2:29]2)=[N:23][CH:24]=[C:25]([CH3:27])[CH:26]=1>>[CH3:20][C:21]1[C:22]([N:28]2[CH2:29][CH2:30][N:31]([C:12]([C:11]3[CH:16]=[CH:17][C:8]([CH2:7][N:3]4[CH2:4][CH2:5][CH2:6][S:2]4(=[O:1])=[O:19])=[CH:9][C:10]=3[F:18])=[O:14])[CH2:32][CH2:33]2)=[N:23][CH:24]=[C:25]([CH3:27])[CH:26]=1

Participants

3

Reactant 2

HCID 584844961-(3,5-Dimethylpyridin-2-yl)piperazineHCID 71252608HCID 71252608, compound

Product 1

HCID 71252065HCID 71252065, compoundYield 87.8%

Procedure

Using methyl 4-(1,1-dioxo-1λ6-isothiazolidin-2-ylmethyl)-2-fluorobenzoate (115 mg) described in Preparation Example 200 and 1-(3,5-dimethylpyridin-2-yl)piperazine (92 mg) described in Preparation Example 79 and by the reaction and treatment in the same manner as in Example 109, the title compound (157 mg) was obtained.

Workup

  1. customdescribed in Preparation Example 79 and by the reaction and treatment in the same manner as in Example 109

Sources & evidence

ORD record
ord-f392c99bfa3f474cb3f4fbc613a9d61b
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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