1-(5-Cyclopropyl-3-methylpyridin-2-yl)piperazine → HCID 71252290, compound

HRID 2411853Notes

Reaction equation

HRID 2411853 reaction equation
[O:1]=[S:2]1(=[O:19])[CH2:6][CH2:5][CH2:4][N:3]1[CH2:7][C:8]1[CH:17]=[CH:16][C:11]([C:12]([O:14]C)=O)=[C:10]([F:18])[CH:9]=1.[CH:20]1([C:23]2[CH:24]=[C:25]([CH3:35])[C:26]([N:29]3[CH2:34][CH2:33][NH:32][CH2:31][CH2:30]3)=[N:27][CH:28]=2)[CH2:22][CH2:21]1>>[CH:20]1([C:23]2[CH:24]=[C:25]([CH3:35])[C:26]([N:29]3[CH2:30][CH2:31][N:32]([C:12]([C:11]4[CH:16]=[CH:17][C:8]([CH2:7][N:3]5[CH2:4][CH2:5][CH2:6][S:2]5(=[O:1])=[O:19])=[CH:9][C:10]=4[F:18])=[O:14])[CH2:33][CH2:34]3)=[N:27][CH:28]=2)[CH2:22][CH2:21]1

Participants

3

Reactant 2

HCID 584847181-(5-Cyclopropyl-3-methylpyridin-2-yl)piperazineHCID 71252608HCID 71252608, compound

Product 1

HCID 71252290HCID 71252290, compoundYield 83%

Procedure

Using methyl 4-(1,1-dioxo-1λ6-isothiazolidin-2-ylmethyl)-2-fluorobenzoate (115 mg) described in Preparation Example 200 and 1-(5-cyclopropyl-3-methylpyridin-2-yl)piperazine (104 mg) described in Preparation Example 83 and by the reaction and treatment in the same manner as in Example 109, the title compound (157 mg) was obtained.

Workup

  1. customdescribed in Preparation Example 83 and by the reaction and treatment in the same manner as in Example 109

Sources & evidence

ORD record
ord-aff1e8510117421d97d32f97f19bfd05
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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