(4-Bromophenyl)[4-(2,4-dimethylphenyl)piperazin-1-yl]methanone → 1-{4-[4-(2,4-Dimethylphenyl)piperazine-1-carbonyl]phenyl}-5-methylimidazolidin-2-one

HRID 2411858Notes

Reaction equation

HRID 2411858 reaction equation
BrC1C=CC(C(N2CCN(C3C=CC(C)=CC=3C)CC2)=O)=CC=1.COC1C=CC(CN2CC(C)NC2=O)=CC=1.[CH3:40][C:41]1[CH:46]=[C:45]([CH3:47])[CH:44]=[CH:43][C:42]=1[N:48]1[CH2:53][CH2:52][N:51]([C:54]([C:56]2[CH:61]=[CH:60][C:59]([N:62]3[CH:66]([CH3:67])[CH2:65][N:64](CC4C=CC(OC)=CC=4)[C:63]3=[O:77])=[CH:58][CH:57]=2)=[O:55])[CH2:50][CH2:49]1>>[CH3:40][C:41]1[CH:46]=[C:45]([CH3:47])[CH:44]=[CH:43][C:42]=1[N:48]1[CH2:53][CH2:52][N:51]([C:54]([C:56]2[CH:61]=[CH:60][C:59]([N:62]3[CH:66]([CH3:67])[CH2:65][NH:64][C:63]3=[O:77])=[CH:58][CH:57]=2)=[O:55])[CH2:50][CH2:49]1

Participants

4

Reactant 3

HCID 58484623(4-Bromophenyl)[4-(2,4-dimethylphenyl)piperazin-1-yl]methanoneHCID 712520041-(4-Methoxybenzyl)-4-methylimidazolidin-2-oneHCID 712530053-{4-[4-(2,4-Dimethylphenyl)piperazine-1-carbonyl]phenyl}-1-(4-methoxybenzyl)-4-methylimidazolidin-2-one

Product 1

HCID 712521421-{4-[4-(2,4-Dimethylphenyl)piperazine-1-carbonyl]phenyl}-5-methylimidazolidin-2-one

Procedure

Using (4-bromophenyl)[4-(2,4-dimethylphenyl)piperazin-1-yl]methanone (149 mg) described in Preparation Example 170 and 1-(4-methoxybenzyl)-4-methylimidazolidin-2-one (106 mg) described in Preparation Example 52 and by the reaction and treatment in the same manner as in Example 506, the title compound (120 mg) was obtained via 3-{4-[4-(2,4-dimethylphenyl)piperazine-1-carbonyl]phenyl}-1-(4-methoxybenzyl)-4-methylimidazolidin-2-one.

Workup

  1. customdescribed in Preparation Example 52 and by the reaction and treatment in the same manner as in Example 506

Sources & evidence

ORD record
ord-b998344cd69f481da580afa4f68fbe2f
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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