1-(3,5,6-Trimethylpyridin-2-yl)piperazine → HCID 71252098, compound

HRID 2411867Notes

Reaction equation

HRID 2411867 reaction equation
[O:1]=[S:2]1(=[O:18])[CH2:6][CH2:5][CH2:4][N:3]1[CH2:7][C:8]1[CH:17]=[CH:16][C:11]([C:12]([O:14]C)=O)=[CH:10][N:9]=1.[CH3:19][C:20]1[C:21]([N:28]2[CH2:33][CH2:32][NH:31][CH2:30][CH2:29]2)=[N:22][C:23]([CH3:27])=[C:24]([CH3:26])[CH:25]=1>>[O:18]=[S:2]1(=[O:1])[CH2:6][CH2:5][CH2:4][N:3]1[CH2:7][C:8]1[N:9]=[CH:10][C:11]([C:12]([N:31]2[CH2:32][CH2:33][N:28]([C:21]3[C:20]([CH3:19])=[CH:25][C:24]([CH3:26])=[C:23]([CH3:27])[N:22]=3)[CH2:29][CH2:30]2)=[O:14])=[CH:16][CH:17]=1

Participants

3

Reactant 2

HCID 584848231-(3,5,6-Trimethylpyridin-2-yl)piperazineHCID 71252272HCID 71252272, compound

Product 1

HCID 71252098HCID 71252098, compoundYield 67.4%

Procedure

Using methyl 6-(1,1-dioxo-1λ6-isothiazolidin-2-ylmethyl)nicotinate (107 mg) described in Preparation Example 45 and 1-(3,5,6-trimethylpyridin-2-yl)piperazine (81 mg) described in Preparation Example 92 and by the reaction and treatment in the same manner as in Example 109, the title compound (118 mg) was obtained.

Workup

  1. customdescribed in Preparation Example 92 and by the reaction and treatment in the same manner as in Example 109

Sources & evidence

ORD record
ord-6a7e18574e0e411090a0f7e187f31fd1
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

Loading…