Ethanol hydrochloride → HCID 86676789, compound

HRID 2411871Notes

Reaction equation

HRID 2411871 reaction equation
[O:1]=[S:2]1(=[O:31])[CH2:6][CH2:5][CH2:4][N:3]1[CH2:7][C:8]1[N:13]=[CH:12][C:11]([C:14]([N:16]2[CH2:21][CH2:20][N:19]([C:22]3[C:27]([CH3:28])=[CH:26][C:25]([CH2:29][CH3:30])=[CH:24][N:23]=3)[CH2:18][CH2:17]2)=[O:15])=[CH:10][CH:9]=1.[ClH:32].C(O)C>C(OCC)(=O)C.CO>[ClH:32].[ClH:32].[O:31]=[S:2]1(=[O:1])[CH2:6][CH2:5][CH2:4][N:3]1[CH2:7][C:8]1[N:13]=[CH:12][C:11]([C:14]([N:16]2[CH2:17][CH2:18][N:19]([C:22]3[C:27]([CH3:28])=[CH:26][C:25]([CH2:29][CH3:30])=[CH:24][N:23]=3)[CH2:20][CH2:21]2)=[O:15])=[CH:10][CH:9]=1

Participants

4

Reactant 2

HCID 21887872Ethanol hydrochlorideHCID 71252481HCID 71252481, compound

Product 1

HCID 86676789HCID 86676789, compound

Reagents, catalysts & solvents 1

HCID 21584119Ethylacetate methanolSolvent

Procedure

Using methyl 6-(1,1-dioxo-1λ6-isothiazolidin-2-ylmethyl)nicotinate (107 mg) described in Preparation Example 45 and 1-(5-ethyl-3-methylpyridin-2-yl)piperazine (81 mg) described in Preparation Example 81 and by the reaction and treatment in the same manner as in Example 109, [6-(1,1-dioxo-1λ6-isothiazolidin-2-ylmethyl)pyridin-3-yl][4-(5-ethyl-3-methylpyridin-2-yl)piperazin-1-yl]methanone (81 mg) was obtained. The obtained [6-(1,1-dioxo-1λ6-isothiazolidin-2-ylmethyl)pyridin-3-yl][4-(5-ethyl-3-methylpyridin-2-yl)piperazin-1-yl]methanone (81 mg) was dissolved in ethyl acetate/methanol, 2N hydrogen chloride/ethanol solution was added, and the solvent was evaporated under reduced pressure. The obtained residue was suspension washed with diisopropyl ether to give the title compound (83 mg).

Workup

  1. customthe solvent was evaporated under reduced pressure
  2. washwashed with diisopropyl ether

Sources & evidence

ORD record
ord-7bf69f6708da4258b595249c457e7fc0
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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