(6-Bromopyridin-3-yl)[4-(3,5-dimethylpyridin-2-yl)piperazin-1-yl]methanone → HCID 71252941, compound

HRID 2411875Notes

Reaction equation

HRID 2411875 reaction equation
BrC1N=CC(C(N2CCN(C3C(C)=CC(C)=CN=3)CC2)=O)=CC=1.COC1C=CC(CN2C[C@H](C)NC2=O)=CC=1.[CH3:40][C:41]1[C:42]([N:48]2[CH2:53][CH2:52][N:51]([C:54]([C:56]3[CH:57]=[CH:58][C:59]([N:62]4[C@@H:66]([CH3:67])[CH2:65][N:64](CC5C=CC(OC)=CC=5)[C:63]4=[O:77])=[N:60][CH:61]=3)=[O:55])[CH2:50][CH2:49]2)=[N:43][CH:44]=[C:45]([CH3:47])[CH:46]=1>>[CH3:40][C:41]1[C:42]([N:48]2[CH2:49][CH2:50][N:51]([C:54]([C:56]3[CH:57]=[CH:58][C:59]([N:62]4[C@@H:66]([CH3:67])[CH2:65][NH:64][C:63]4=[O:77])=[N:60][CH:61]=3)=[O:55])[CH2:52][CH2:53]2)=[N:43][CH:44]=[C:45]([CH3:47])[CH:46]=1

Participants

4

Reactant 3

HCID 58484661(6-Bromopyridin-3-yl)[4-(3,5-dimethylpyridin-2-yl)piperazin-1-yl]methanoneHCID 71252003HCID 71252003, compoundHCID 71252186HCID 71252186, compound

Product 1

HCID 71252941HCID 71252941, compound

Procedure

Using (6-bromopyridin-3-yl)[4-(3,5-dimethylpyridin-2-yl)piperazin-1-yl]methanone (150 mg) described in Preparation Example 127 and (S)-1-(4-methoxybenzyl)-4-methylimidazolidin-2-one (106 mg) described in Preparation Example 204 and by the reaction and treatment in the same manner as in Example 426, the title compound (96 mg) was obtained via (S)-3-{5-[4-(3,5-dimethylpyridin-2-yl)piperazine-1-carbonyl]pyridin-2-yl}-1-(4-methoxybenzyl)-4-methylimidazolidin-2-one.

Workup

  1. customdescribed in Preparation Example 204 and by the reaction and treatment in the same manner as in Example 426

Sources & evidence

ORD record
ord-dee30bbf1d6d4b51bafb70d6571371a9
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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