(4-Bromo-3-fluorophenyl)[4-(3,5-dimethylpyridin-2-yl)piperazin-1-yl]methanone → HCID 71252152, compound

HRID 2411882Notes

Reaction equation

HRID 2411882 reaction equation
BrC1C=CC(C(N2CCN(C3C(C)=CC(C)=CN=3)CC2)=O)=CC=1F.COC1C=CC(CN2CC(C)NC2=O)=CC=1.[CH3:41][C:42]1[C:43]([N:49]2[CH2:54][CH2:53][N:52]([C:55]([C:57]3[CH:62]=[CH:61][C:60]([N:63]4[CH:67]([CH3:68])[CH2:66][N:65](CC5C=CC(OC)=CC=5)[C:64]4=[O:78])=[C:59]([F:79])[CH:58]=3)=[O:56])[CH2:51][CH2:50]2)=[N:44][CH:45]=[C:46]([CH3:48])[CH:47]=1>>[CH3:41][C:42]1[C:43]([N:49]2[CH2:50][CH2:51][N:52]([C:55]([C:57]3[CH:62]=[CH:61][C:60]([N:63]4[CH:67]([CH3:68])[CH2:66][NH:65][C:64]4=[O:78])=[C:59]([F:79])[CH:58]=3)=[O:56])[CH2:53][CH2:54]2)=[N:44][CH:45]=[C:46]([CH3:48])[CH:47]=1

Participants

4

Reactant 3

HCID 58484572(4-Bromo-3-fluorophenyl)[4-(3,5-dimethylpyridin-2-yl)piperazin-1-yl]methanoneHCID 71251972HCID 71251972, compoundHCID 712520041-(4-Methoxybenzyl)-4-methylimidazolidin-2-one

Product 1

HCID 71252152HCID 71252152, compound

Procedure

Using (4-bromo-3-fluorophenyl) [4-(3,5-dimethylpyridin-2-yl)piperazin-1-yl]methanone (157 mg) described in Preparation Example 125 and 1-(4-methoxybenzyl)-4-methylimidazolidin-2-one (106 mg) described in Preparation Example 52 and by the reaction and treatment in the same manner as in Example 506, the title compound (86 mg) was obtained via 3-{4-[4-(3,5-dimethylpyridin-2-yl)piperazine-1-carbonyl]-2-fluorophenyl}-1-(4-methoxybenzyl)-4-methylimidazolidin-2-one.

Workup

  1. customdescribed in Preparation Example 52 and by the reaction and treatment in the same manner as in Example 506

Sources & evidence

ORD record
ord-4f574b5420ed4a43be43b0d37302cbdc
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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