HRID2411884

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：Cc1cc(C)c(N2CCN(C(=O)c3ccc(Br)cc3F)CC2)nc1C

HCID58484847

未命名化合物

HCID71252004

未命名化合物

结构：COc1ccc(CN2CC(C)N(c3ccc(C(=O)N4CCN(c5nc(C)c(C)cc5C)CC4)c(F)c3)C2=O)cc1

HCID71252602

未命名化合物

PRODUCTS

生成物

结构：Cc1cc(C)c(N2CCN(C(=O)c3ccc(N4C(=O)NCC4C)cc3F)CC2)nc1C

HCID71252687

未命名化合物

PROCEDURE

实验过程

Using (4-bromo-2-fluorophenyl)[4-(3,5,6-trimethylpyridin-2-yl)piperazin-1-yl]methanone (163 mg) described in Preparation Example 128 and 1-(4-methoxybenzyl)-4-methylimidazolidin-2-one (106 mg) described in Preparation Example 52 and by the reaction and treatment in the same manner as in Example 506, the title compound (79 mg) was obtained via 3-{3-fluoro-4-[4-(3,5,6-trimethylpyridin-2-yl)piperazine-1-carbonyl]phenyl}-1-(4-methoxybenzyl)-4-methylimidazolidin-2-one.

WORKUP

后处理

customdescribed in Preparation Example 52 and by the reaction and treatment in the same manner as in Example 506

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-9f5d625e48b84cafad7841313b2cc0f2
来源数据集: uspto-grants-2014_08
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08816079B2
来源说明: uspto-grants-2014_08

反应 SMILES

BrC1C=CC(C(N2CCN(C3C(C)=CC(C)=C(C)N=3)CC2)=O)=C(F)C=1.COC1C=CC(CN2CC(C)NC2=O)=CC=1.[F:42][C:43]1[CH:44]=[C:45]([N:66]2[CH:70]([CH3:71])[CH2:69][N:68](CC3C=CC(OC)=CC=3)[C:67]2=[O:81])[CH:46]=[CH:47][C:48]=1[C:49]([N:51]1[CH2:56][CH2:55][N:54]([C:57]2[C:62]([CH3:63])=[CH:61][C:60]([CH3:64])=[C:59]([CH3:65])[N:58]=2)[CH2:53][CH2:52]1)=[O:50]>>[F:42][C:43]1[CH:44]=[C:45]([N:66]2[CH:70]([CH3:71])[CH2:69][NH:68][C:67]2=[O:81])[CH:46]=[CH:47][C:48]=1[C:49]([N:51]1[CH2:52][CH2:53][N:54]([C:57]2[C:62]([CH3:63])=[CH:61][C:60]([CH3:64])=[C:59]([CH3:65])[N:58]=2)[CH2:55][CH2:56]1)=[O:50]