(4-Iodophenyl)[4-(3,5,6-trimethylpyridin-2-yl)piperazin-1-yl]methanone → HCID 71251895, compound

HRID 2411885Notes

Reaction equation

HRID 2411885 reaction equation
IC1C=CC(C(N2CCN(C3C(C)=CC(C)=C(C)N=3)CC2)=O)=CC=1.COC1C=CC(CN2CC(C)NC2=O)=CC=1.COC1C=CC(C[N:48]2[CH2:52][CH:51]([CH3:53])[N:50]([C:54]3[CH:59]=[CH:58][C:57]([C:60]([N:62]4[CH2:67][CH2:66][N:65]([C:68]5[C:73]([CH3:74])=[CH:72][C:71]([CH3:75])=[C:70]([CH3:76])[N:69]=5)[CH2:64][CH2:63]4)=[O:61])=[CH:56][CH:55]=3)[C:49]2=[O:77])=CC=1>>[CH3:53][CH:51]1[N:50]([C:54]2[CH:55]=[CH:56][C:57]([C:60]([N:62]3[CH2:63][CH2:64][N:65]([C:68]4[C:73]([CH3:74])=[CH:72][C:71]([CH3:75])=[C:70]([CH3:76])[N:69]=4)[CH2:66][CH2:67]3)=[O:61])=[CH:58][CH:59]=2)[C:49](=[O:77])[NH:48][CH2:52]1

Participants

4

Reactant 3

HCID 58484793(4-Iodophenyl)[4-(3,5,6-trimethylpyridin-2-yl)piperazin-1-yl]methanoneHCID 71251998HCID 71251998, compoundHCID 712520041-(4-Methoxybenzyl)-4-methylimidazolidin-2-one

Product 1

HCID 71251895HCID 71251895, compound

Procedure

Using (4-iodophenyl)[4-(3,5,6-trimethylpyridin-2-yl)piperazin-1-yl]methanone (174 mg) described in Preparation Example 120 and 1-(4-methoxybenzyl)-4-methylimidazolidin-2-one (106 mg) described in Preparation Example 52 and by the reaction and treatment in the same manner as in Example 506, the title compound (135 mg) was obtained via 1-(4-methoxybenzyl)-4-methyl-3-{4-[4-(3,5,6-trimethylpyridin-2-yl)piperazine-1-carbonyl]phenyl}imidazolidin-2-one.

Workup

  1. customdescribed in Preparation Example 52 and by the reaction and treatment in the same manner as in Example 506

Sources & evidence

ORD record
ord-3e221229fa654277abdd03ca2fa268ee
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

Loading…