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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2411888Generated: November 4, 2026

3-Benzyloxymethyl-5-methylimidazolidine-2,4-dione → 3-Benzyloxymethyl-1-{4-[4-(5-cyclopropyl-3-methylpyridin-2-yl)piperazine-1-carbonyl]phenyl}-5-methylimidazolidine-2,4-dione

https://huagongshe.com/reaction/2411888

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-Benzyloxymethyl-5-methylimidazolidine-2,4-dioneHCID 71252274—
Reactant(4-Bromophenyl)[4-(5-cyclopropyl-3-methylpyridin-2-yl)piperazin-1-yl]methanoneHCID 71252330—
Product3-Benzyloxymethyl-1-{4-[4-(5-cyclopropyl-3-methylpyridin-2-yl)piperazine-1-carbonyl]phenyl}-5-methylimidazolidine-2,4-dioneHCID 7125304964.6%

Reaction Steps

Using (4-bromophenyl)[4-(5-cyclopropyl-3-methylpyridin-2-yl)piperazin-1-yl]methanone (320 mg) described in Preparation Example 185 and 3-benzyloxymethyl-5-methylimidazolidine-2,4-dione (225 mg) described in Preparation Example 206 and by the reaction and treatment in the same manner as in Example 536, the title compound (286 mg) was obtained.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08816079B2
Source datasetuspto-grants-2014_08
ORD IDord-a6649b0f37db4b25956ed5edce5ecf04
Source noteuspto-grants-2014_08