[4-(3,5-Dimethylpyridin-2-yl)piperazin-1-yl](4-iodophenyl)methanone → HCID 71252527, compound

HRID 2411891Notes

Reaction equation

HRID 2411891 reaction equation
CC1C(N2CCN(C(C3C=CC(I)=CC=3)=O)CC2)=NC=C(C)C=1.C(C1CN(CC2C=CC(OC)=CC=2)C(=O)N1)C.[CH3:41][C:42]1[C:43]([N:49]2[CH2:54][CH2:53][N:52]([C:55]([C:57]3[CH:62]=[CH:61][C:60]([N:63]4[CH:67]([CH2:68][CH3:69])[CH2:66][N:65](CC5C=CC(OC)=CC=5)[C:64]4=[O:79])=[CH:59][CH:58]=3)=[O:56])[CH2:51][CH2:50]2)=[N:44][CH:45]=[C:46]([CH3:48])[CH:47]=1>>[CH3:41][C:42]1[C:43]([N:49]2[CH2:50][CH2:51][N:52]([C:55]([C:57]3[CH:58]=[CH:59][C:60]([N:63]4[CH:67]([CH2:68][CH3:69])[CH2:66][NH:65][C:64]4=[O:79])=[CH:61][CH:62]=3)=[O:56])[CH2:53][CH2:54]2)=[N:44][CH:45]=[C:46]([CH3:48])[CH:47]=1

Participants

4

Reactant 3

HCID 58484535[4-(3,5-Dimethylpyridin-2-yl)piperazin-1-yl](4-iodophenyl)methanoneHCID 71252007HCID 71252007, compoundHCID 71252369HCID 71252369, compound

Product 1

HCID 71252527HCID 71252527, compound

Procedure

Using [4-(3,5-dimethylpyridin-2-yl)piperazin-1-yl](4-iodophenyl)methanone (253 mg) described in Preparation Example 113 and 4-ethyl-1-(4-methoxybenzyl)imidazolidin-2-one (140 mg) described in Preparation Example 208 and by the reaction and treatment in the same manner as in Example 506, the title compound (162 mg) was obtained via 3-{4-[4-(3,5-dimethylpyridin-2-yl)piperazine-1-carbonyl]phenyl}-4-ethyl-1-(4-methoxybenzyl)imidazolidin-2-one.

Workup

  1. customdescribed in Preparation Example 208 and by the reaction and treatment in the same manner as in Example 506

Sources & evidence

ORD record
ord-e16f0225505b49268e7918d56d7a389d
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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