(6-Bromopyridin-3-yl)[4-(3,5-dimethylpyridin-2-yl)piperazin-1-yl]methanone → HCID 71251864, compound

HRID 2411893Notes

Reaction equation

HRID 2411893 reaction equation
BrC1N=CC(C(N2CCN(C3C(C)=CC(C)=CN=3)CC2)=O)=CC=1.C(C1CN(CC2C=CC(OC)=CC=2)C(=O)N1)(C)C.[CH3:42][C:43]1[C:44]([N:50]2[CH2:55][CH2:54][N:53]([C:56]([C:58]3[CH:59]=[CH:60][C:61]([N:64]4[CH:68]([CH:69]([CH3:71])[CH3:70])[CH2:67][N:66](CC5C=CC(OC)=CC=5)[C:65]4=[O:81])=[N:62][CH:63]=3)=[O:57])[CH2:52][CH2:51]2)=[N:45][CH:46]=[C:47]([CH3:49])[CH:48]=1>>[CH3:42][C:43]1[C:44]([N:50]2[CH2:51][CH2:52][N:53]([C:56]([C:58]3[CH:59]=[CH:60][C:61]([N:64]4[CH:68]([CH:69]([CH3:70])[CH3:71])[CH2:67][NH:66][C:65]4=[O:81])=[N:62][CH:63]=3)=[O:57])[CH2:54][CH2:55]2)=[N:45][CH:46]=[C:47]([CH3:49])[CH:48]=1

Participants

4

Reactant 3

HCID 58484661(6-Bromopyridin-3-yl)[4-(3,5-dimethylpyridin-2-yl)piperazin-1-yl]methanoneHCID 68089263HCID 68089263, compoundHCID 71252252HCID 71252252, compound

Product 1

HCID 71251864HCID 71251864, compound

Procedure

Using (6-bromopyridin-3-yl)[4-(3,5-dimethylpyridin-2-yl)piperazin-1-yl]methanone (225 mg) described in Preparation Example 127 and 4-isopropyl-1-(4-methoxybenzyl)imidazolidin-2-one (149 mg) described in Preparation Example 210 and by the reaction and treatment in the same manner as in Example 505, the title compound (52 mg) was obtained via 3-{5-[4-(3,5-dimethylpyridin-2-yl)piperazine-1-carbonyl]pyridin-2-yl}-4-isopropyl-1-(4-methoxybenzyl)imidazolidin-2-one.

Workup

  1. customdescribed in Preparation Example 210 and by the reaction and treatment in the same manner as in Example 505

Sources & evidence

ORD record
ord-2b7e1be91da343b7a1b47c30eeb3b5ca
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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