Methyl iodide → HCID 71252744, compound

HRID 2411899Notes

Reaction equation

[CH3:1][CH:2]1[N:6]([C:7]2[CH:12]=[CH:11][C:10]([C:13]([N:15]3[CH2:20][CH2:19][N:18]([C:21]4[C:26]([CH3:27])=[CH:25][C:24]([CH3:28])=[C:23]([CH3:29])[N:22]=4)[CH2:17][CH2:16]3)=[O:14])=[CH:9][CH:8]=2)[C:5](=[O:30])[NH:4][C:3]1=[O:31].[CH3:32]I>>[CH3:32][N:4]1[C:3](=[O:31])[CH:2]([CH3:1])[N:6]([C:7]2[CH:12]=[CH:11][C:10]([C:13]([N:15]3[CH2:16][CH2:17][N:18]([C:21]4[C:26]([CH3:27])=[CH:25][C:24]([CH3:28])=[C:23]([CH3:29])[N:22]=4)[CH2:19][CH2:20]3)=[O:14])=[CH:9][CH:8]=2)[C:5]1=[O:30]

Participants

Reactant 2

HCID 6328Methyl iodide

HCID 71252576HCID 71252576, compound

Product 1

HCID 71252744HCID 71252744, compound

Procedure

Using 5-methyl-1-{4-[4-(3,5,6-trimethylpyridin-2-yl)piperazine-1-carbonyl]phenyl}imidazolidine-2,4-dione (50 mg) described in Example 550 and methyl iodide (8.1 μL) and by the reaction and treatment in the same manner as in Example 551, the title compound (27 mg) was obtained.

Sources & evidence

ORD record: ord-81be83246e2e4888b0b5ce70c0052fe5
Source dataset: uspto-grants-2014_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08816079B2

Reaction notes

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