Methyl iodide → HCID 71253154, compound

HRID 2411900Notes

Reaction equation

[F:1][C:2]1[CH:3]=[C:4]([N:25]2[CH:29]([CH3:30])[C:28](=[O:31])[NH:27][C:26]2=[O:32])[CH:5]=[CH:6][C:7]=1[C:8]([N:10]1[CH2:15][CH2:14][N:13]([C:16]2[C:21]([CH3:22])=[CH:20][C:19]([CH3:23])=[C:18]([CH3:24])[N:17]=2)[CH2:12][CH2:11]1)=[O:9].[CH3:33]I>>[F:1][C:2]1[CH:3]=[C:4]([N:25]2[CH:29]([CH3:30])[C:28](=[O:31])[N:27]([CH3:33])[C:26]2=[O:32])[CH:5]=[CH:6][C:7]=1[C:8]([N:10]1[CH2:15][CH2:14][N:13]([C:16]2[C:21]([CH3:22])=[CH:20][C:19]([CH3:23])=[C:18]([CH3:24])[N:17]=2)[CH2:12][CH2:11]1)=[O:9]

Participants

Reactant 2

HCID 6328Methyl iodide

HCID 71252015HCID 71252015, compound

Product 1

HCID 71253154HCID 71253154, compound

Procedure

Using 1-{3-fluoro-4-[4-(3,5,6-trimethylpyridin-2-yl)piperazine-1-carbonyl]phenyl}-5-methylimidazolidine-2,4-dione (50 mg) described in Example 552 and methyl iodide (7.8 μL) and by the reaction and treatment in the same manner as in Example 551, the title compound (27 mg) was obtained.

Sources & evidence

ORD record: ord-4ef3f3bec214499184c15633c5469ee8
Source dataset: uspto-grants-2014_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08816079B2

Reaction notes

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