(4-Bromo-2-fluorophenyl)[4-(5-ethyl-3-methylpyridin-2-yl)piperazin-1-yl]methanone → HCID 71251934, compound

HRID 2411902Notes

Reaction equation

HRID 2411902 reaction equation
BrC1C=CC(C(N2CCN(C3C(C)=CC(CC)=CN=3)CC2)=O)=C(F)C=1.COC1C=CC(CN2CC(C)NC2=O)=CC=1.[CH2:42]([C:44]1[CH:45]=[C:46]([CH3:81])[C:47]([N:50]2[CH2:55][CH2:54][N:53]([C:56]([C:58]3[CH:63]=[CH:62][C:61]([N:64]4[CH:68]([CH3:69])[CH2:67][N:66](CC5C=CC(OC)=CC=5)[C:65]4=[O:79])=[CH:60][C:59]=3[F:80])=[O:57])[CH2:52][CH2:51]2)=[N:48][CH:49]=1)[CH3:43]>>[CH2:42]([C:44]1[CH:45]=[C:46]([CH3:81])[C:47]([N:50]2[CH2:55][CH2:54][N:53]([C:56]([C:58]3[CH:63]=[CH:62][C:61]([N:64]4[CH:68]([CH3:69])[CH2:67][NH:66][C:65]4=[O:79])=[CH:60][C:59]=3[F:80])=[O:57])[CH2:52][CH2:51]2)=[N:48][CH:49]=1)[CH3:43]

Participants

4

Reactant 3

HCID 58484537(4-Bromo-2-fluorophenyl)[4-(5-ethyl-3-methylpyridin-2-yl)piperazin-1-yl]methanoneHCID 712520041-(4-Methoxybenzyl)-4-methylimidazolidin-2-oneHCID 71252904HCID 71252904, compound

Product 1

HCID 71251934HCID 71251934, compound

Procedure

Using (4-bromo-2-fluorophenyl)[4-(5-ethyl-3-methylpyridin-2-yl)piperazin-1-yl]methanone (163 mg) described in Preparation Example 211 and 1-(4-methoxybenzyl)-4-methylimidazolidin-2-one (88 mg) described in Preparation Example 52 and by the reaction and treatment in the same manner as in Example 506, the title compound (89 mg) was obtained via 3-{4-[4-(5-ethyl-3-methylpyridin-2-yl)piperazine-1-carbonyl]-3-fluorophenyl}-1-(4-methoxybenzyl)-4-methylimidazolidin-2-one.

Workup

  1. customdescribed in Preparation Example 52 and by the reaction and treatment in the same manner as in Example 506

Sources & evidence

ORD record
ord-635dbecd78954327b41ad7398c668163
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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