(6-Bromopyridin-3-yl)[4-(5-ethyl-3-methylpyridin-2-yl)piperazin-1-yl]methanone → HCID 71252899, compound

HRID 2411903Notes

Reaction equation

HRID 2411903 reaction equation
BrC1N=CC(C(N2CCN(C3C(C)=CC(CC)=CN=3)CC2)=O)=CC=1.COC1C=CC(CN2CC(C)NC2=O)=CC=1.[CH2:41]([C:43]1[CH:44]=[C:45]([CH3:79])[C:46]([N:49]2[CH2:54][CH2:53][N:52]([C:55]([C:57]3[CH:58]=[CH:59][C:60]([N:63]4[CH:67]([CH3:68])[CH2:66][N:65](CC5C=CC(OC)=CC=5)[C:64]4=[O:78])=[N:61][CH:62]=3)=[O:56])[CH2:51][CH2:50]2)=[N:47][CH:48]=1)[CH3:42]>>[CH2:41]([C:43]1[CH:44]=[C:45]([CH3:79])[C:46]([N:49]2[CH2:54][CH2:53][N:52]([C:55]([C:57]3[CH:58]=[CH:59][C:60]([N:63]4[CH:67]([CH3:68])[CH2:66][NH:65][C:64]4=[O:78])=[N:61][CH:62]=3)=[O:56])[CH2:51][CH2:50]2)=[N:47][CH:48]=1)[CH3:42]

Participants

4

Reactant 3

HCID 58484652(6-Bromopyridin-3-yl)[4-(5-ethyl-3-methylpyridin-2-yl)piperazin-1-yl]methanoneHCID 712520041-(4-Methoxybenzyl)-4-methylimidazolidin-2-oneHCID 71252206HCID 71252206, compound

Product 1

HCID 71252899HCID 71252899, compound

Procedure

Using (6-bromopyridin-3-yl) [4-(5-ethyl-3-methylpyridin-2-yl)piperazin-1-yl]methanone (156 mg) described in Preparation Example 145 and 1-(4-methoxybenzyl)-4-methylimidazolidin-2-one (88 mg) described in Preparation Example 52 and by the reaction and treatment in the same manner as in Example 505, the title compound (110 mg) was obtained via 3-{5-[4-(5-ethyl-3-methylpyridin-2-yl)piperazine-1-carbonyl]pyridin-2-yl}-1-(4-methoxybenzyl)-4-methylimidazolidin-2-one.

Workup

  1. customdescribed in Preparation Example 52 and by the reaction and treatment in the same manner as in Example 505

Sources & evidence

ORD record
ord-a31a8878a94140149c54fdb616c898e1
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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