HCID 71251959, compound → HCID 71252164, compound

HRID 2411904Notes

Reaction equation

HRID 2411904 reaction equation
BrC1C=CC(C(N2CCN(C3C(C)=CC(CC)=CN=3)CC2)=O)=CC=1.COC1C=CC(CN2CC(C)NC2=O)=CC=1.[CH2:41]([C:43]1[CH:44]=[C:45]([CH3:79])[C:46]([N:49]2[CH2:54][CH2:53][N:52]([C:55]([C:57]3[CH:62]=[CH:61][C:60]([N:63]4[CH:67]([CH3:68])[CH2:66][N:65](CC5C=CC(OC)=CC=5)[C:64]4=[O:78])=[CH:59][CH:58]=3)=[O:56])[CH2:51][CH2:50]2)=[N:47][CH:48]=1)[CH3:42]>>[CH2:41]([C:43]1[CH:44]=[C:45]([CH3:79])[C:46]([N:49]2[CH2:50][CH2:51][N:52]([C:55]([C:57]3[CH:58]=[CH:59][C:60]([N:63]4[CH:67]([CH3:68])[CH2:66][NH:65][C:64]4=[O:78])=[CH:61][CH:62]=3)=[O:56])[CH2:53][CH2:54]2)=[N:47][CH:48]=1)[CH3:42]

Participants

4

Reactant 3

HCID 71251959HCID 71251959, compoundHCID 712520041-(4-Methoxybenzyl)-4-methylimidazolidin-2-oneHCID 71252713HCID 71252713, compound

Product 1

HCID 71252164HCID 71252164, compound

Procedure

Using (4-bromophenyl)[4-(5-ethyl-3-methylpyridin-2-yl)piperazin-1-yl]methanone (155 mg) described in Preparation Example 212 and 1-(4-methoxybenzyl)-4-methylimidazolidin-2-one (88 mg) described in Preparation Example 52 and by the reaction and treatment in the same manner as in Example 506, the title compound (117 mg) was obtained via 3-{4-[4-(5-ethyl-3-methylpyridin-2-yl)piperazine-1-carbonyl]phenyl}-1-(4-methoxybenzyl)-4-methylimidazolidin-2-one.

Workup

  1. customdescribed in Preparation Example 52 and by the reaction and treatment in the same manner as in Example 506

Sources & evidence

ORD record
ord-d7d632141ad4498fb11eb39e8f2ceda3
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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