HCID 2726691, compound → HCID 71252227, compound

HRID 2411905Notes

Reaction equation

HRID 2411905 reaction equation
CC1C(N2CCN(C(C3C=CC(I)=CC=3)=O)CC2)=NC=C(C)C=1.COC1C=CC(CN2C(=O)CNC2=O)=CC=1.[CH3:40][C:41]1[C:42]([N:48]2[CH2:53][CH2:52][N:51]([C:54]([C:56]3[CH:61]=[CH:60][C:59]([N:62]4[CH2:66][C:65](=[O:67])[N:64](CC5C=CC(OC)=CC=5)[C:63]4=[O:77])=[CH:58][CH:57]=3)=[O:55])[CH2:50][CH2:49]2)=[N:43][CH:44]=[C:45]([CH3:47])[CH:46]=1>>[CH3:40][C:41]1[C:42]([N:48]2[CH2:49][CH2:50][N:51]([C:54]([C:56]3[CH:61]=[CH:60][C:59]([N:62]4[CH2:66][C:65](=[O:67])[NH:64][C:63]4=[O:77])=[CH:58][CH:57]=3)=[O:55])[CH2:52][CH2:53]2)=[N:43][CH:44]=[C:45]([CH3:47])[CH:46]=1

Participants

4

Reactant 3

HCID 2726691HCID 2726691, compoundHCID 58484535[4-(3,5-Dimethylpyridin-2-yl)piperazin-1-yl](4-iodophenyl)methanoneHCID 71252176HCID 71252176, compound

Product 1

HCID 71252227HCID 71252227, compound

Procedure

Using [4-(3,5-dimethylpyridin-2-yl)piperazin-1-yl](4-iodophenyl)methanone (337 mg) described in Preparation Example 113 and 3-(4-methoxybenzyl)imidazolidine-2,4-dione (176 mg) described in Preparation Example 213 and by the reaction and treatment in the same manner as in Example 508, the title compound (61 mg) was obtained via 1-{4-[4-(3,5-dimethylpyridin-2-yl)piperazine-1-carbonyl]phenyl}-3-(4-methoxybenzyl)imidazolidine-2,4-dione.

Workup

  1. customdescribed in Preparation Example 213 and by the reaction and treatment in the same manner as in Example 508

Sources & evidence

ORD record
ord-aec081ad8cd144fa9b5b7f5e15c851fe
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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