HCID 2726691, compound → HCID 71252525, compound

HRID 2411906Notes

Reaction equation

HRID 2411906 reaction equation
BrC1C=CC(C(N2CCN(C3C(C)=CC(C)=CN=3)CC2)=O)=C(F)C=1.COC1C=CC(CN2C(=O)CNC2=O)=CC=1.[CH3:41][C:42]1[C:43]([N:49]2[CH2:54][CH2:53][N:52]([C:55]([C:57]3[CH:62]=[CH:61][C:60]([N:63]4[CH2:67][C:66](=[O:68])[N:65](CC5C=CC(OC)=CC=5)[C:64]4=[O:78])=[CH:59][C:58]=3[F:79])=[O:56])[CH2:51][CH2:50]2)=[N:44][CH:45]=[C:46]([CH3:48])[CH:47]=1>>[CH3:41][C:42]1[C:43]([N:49]2[CH2:50][CH2:51][N:52]([C:55]([C:57]3[CH:62]=[CH:61][C:60]([N:63]4[CH2:67][C:66](=[O:68])[NH:65][C:64]4=[O:78])=[CH:59][C:58]=3[F:79])=[O:56])[CH2:53][CH2:54]2)=[N:44][CH:45]=[C:46]([CH3:48])[CH:47]=1

Participants

4

Reactant 3

HCID 2726691HCID 2726691, compoundHCID 58484626(4-Bromo-2-fluorophenyl)[4-(3,5-dimethylpyridin-2-yl)piperazin-1-yl]methanoneHCID 71251942HCID 71251942, compound

Product 1

HCID 71252525HCID 71252525, compound

Procedure

Using (4-bromo-2-fluorophenyl)[4-(3,5-dimethylpyridin-2-yl)piperazin-1-yl]methanone (314 mg) described in Preparation Example 114 and 3-(4-methoxybenzyl)imidazolidine-2,4-dione (176 mg) described in Preparation Example 213 and by the reaction and treatment in the same manner as in Example 508, the title compound (185 mg) was obtained via 1-{4-[4-(3,5-dimethylpyridin-2-yl)piperazine-1-carbonyl]-3-fluorophenyl}-3-(4-methoxybenzyl)imidazolidine-2,4-dione.

Workup

  1. customdescribed in Preparation Example 213 and by the reaction and treatment in the same manner as in Example 508

Sources & evidence

ORD record
ord-7c61ab470d5646a5bf33262745c1d7d1
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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