HCID 2726691, compound → HCID 71252139, compound

HRID 2411907Notes

Reaction equation

HRID 2411907 reaction equation
BrC1N=CC(C(N2CCN(C3C(C)=CC(C)=CN=3)CC2)=O)=CC=1.COC1C=CC(CN2C(=O)CNC2=O)=CC=1.[CH3:40][C:41]1[C:42]([N:48]2[CH2:53][CH2:52][N:51]([C:54]([C:56]3[CH:57]=[CH:58][C:59]([N:62]4[CH2:66][C:65](=[O:67])[N:64](CC5C=CC(OC)=CC=5)[C:63]4=[O:77])=[N:60][CH:61]=3)=[O:55])[CH2:50][CH2:49]2)=[N:43][CH:44]=[C:45]([CH3:47])[CH:46]=1>>[CH3:40][C:41]1[C:42]([N:48]2[CH2:49][CH2:50][N:51]([C:54]([C:56]3[CH:57]=[CH:58][C:59]([N:62]4[CH2:66][C:65](=[O:67])[NH:64][C:63]4=[O:77])=[N:60][CH:61]=3)=[O:55])[CH2:52][CH2:53]2)=[N:43][CH:44]=[C:45]([CH3:47])[CH:46]=1

Participants

4

Reactant 3

HCID 2726691HCID 2726691, compoundHCID 58484661(6-Bromopyridin-3-yl)[4-(3,5-dimethylpyridin-2-yl)piperazin-1-yl]methanoneHCID 71252699HCID 71252699, compound

Product 1

HCID 71252139HCID 71252139, compound

Procedure

Using (6-bromopyridin-3-yl)[4-(3,5-dimethylpyridin-2-yl)piperazin-1-yl]methanone (300 mg) described in Preparation Example 127 and 3-(4-methoxybenzyl)imidazolidine-2,4-dione (176 mg) described in Preparation Example 213 and by the reaction and treatment in the same manner as in Example 508, the title compound (165 mg) was obtained via 1-{5-[4-(3,5-dimethylpyridin-2-yl)piperazine-1-carbonyl]pyridin-2-yl}-3-(4-methoxybenzyl)imidazolidine-2,4-dione.

Workup

  1. customdescribed in Preparation Example 213 and by the reaction and treatment in the same manner as in Example 508

Sources & evidence

ORD record
ord-8e774d70279d4bff850e2f960b2b7834
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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