(4-Bromo-2-fluorophenyl)[4-(3,5-dimethylpyridin-2-yl)piperazin-1-yl]methanone → HCID 71251987, compound

HRID 2411911Notes

Reaction equation

HRID 2411911 reaction equation
BrC1C=CC(C(N2CCN(C3C(C)=CC(C)=CN=3)CC2)=O)=C(F)C=1.C(C1NC(=O)N(CC2C=CC(OC)=CC=2)C1=O)C.[CH3:43][C:44]1[C:45]([N:51]2[CH2:56][CH2:55][N:54]([C:57]([C:59]3[CH:64]=[CH:63][C:62]([N:65]4[CH:69]([CH2:70][CH3:71])[C:68](=[O:72])[N:67](CC5C=CC(OC)=CC=5)[C:66]4=[O:82])=[CH:61][C:60]=3[F:83])=[O:58])[CH2:53][CH2:52]2)=[N:46][CH:47]=[C:48]([CH3:50])[CH:49]=1>>[CH3:43][C:44]1[C:45]([N:51]2[CH2:52][CH2:53][N:54]([C:57]([C:59]3[CH:64]=[CH:63][C:62]([N:65]4[CH:69]([CH2:70][CH3:71])[C:68](=[O:72])[NH:67][C:66]4=[O:82])=[CH:61][C:60]=3[F:83])=[O:58])[CH2:55][CH2:56]2)=[N:46][CH:47]=[C:48]([CH3:50])[CH:49]=1

Participants

4

Reactant 3

HCID 58484626(4-Bromo-2-fluorophenyl)[4-(3,5-dimethylpyridin-2-yl)piperazin-1-yl]methanoneHCID 71252043HCID 71252043, compoundHCID 71252282HCID 71252282, compound

Product 1

HCID 71251987HCID 71251987, compound

Procedure

Using (4-bromo-2-fluorophenyl)[4-(3,5-dimethylpyridin-2-yl)piperazin-1-yl]methanone (314 mg) described in Preparation Example 114 and 5-ethyl-3-(4-methoxybenzyl)imidazolidine-2,4-dione (176 mg) described in Preparation Example 207 and by the reaction and treatment in the same manner as in Example 508, the title compound (190 mg) was obtained via 1-{4-[4-(3,5-dimethylpyridin-2-yl)piperazine-1-carbonyl]-3-fluorophenyl}-5-ethyl-3-(4-methoxybenzyl)imidazolidine-2,4-dione.

Workup

  1. customdescribed in Preparation Example 207 and by the reaction and treatment in the same manner as in Example 508

Sources & evidence

ORD record
ord-2f8660669cc6474bb21f716da2313a1b
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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