(6-Bromopyridin-3-yl)[4-(3,5-dimethylpyridin-2-yl)piperazin-1-yl]methanone → HCID 71252630, compound

HRID 2411912Notes

Reaction equation

HRID 2411912 reaction equation
BrC1N=CC(C(N2CCN(C3C(C)=CC(C)=CN=3)CC2)=O)=CC=1.C(C1NC(=O)N(CC2C=CC(OC)=CC=2)C1=O)C.[CH3:42][C:43]1[C:44]([N:50]2[CH2:55][CH2:54][N:53]([C:56]([C:58]3[CH:59]=[CH:60][C:61]([N:64]4[CH:68]([CH2:69][CH3:70])[C:67](=[O:71])[N:66](CC5C=CC(OC)=CC=5)[C:65]4=[O:81])=[N:62][CH:63]=3)=[O:57])[CH2:52][CH2:51]2)=[N:45][CH:46]=[C:47]([CH3:49])[CH:48]=1>>[CH3:42][C:43]1[C:44]([N:50]2[CH2:51][CH2:52][N:53]([C:56]([C:58]3[CH:59]=[CH:60][C:61]([N:64]4[CH:68]([CH2:69][CH3:70])[C:67](=[O:71])[NH:66][C:65]4=[O:81])=[N:62][CH:63]=3)=[O:57])[CH2:54][CH2:55]2)=[N:45][CH:46]=[C:47]([CH3:49])[CH:48]=1

Participants

4

Reactant 3

HCID 58484661(6-Bromopyridin-3-yl)[4-(3,5-dimethylpyridin-2-yl)piperazin-1-yl]methanoneHCID 71252043HCID 71252043, compoundHCID 71253241HCID 71253241, compound

Product 1

HCID 71252630HCID 71252630, compound

Procedure

Using (6-bromopyridin-3-yl)[4-(3,5-dimethylpyridin-2-yl)piperazin-1-yl]methanone (300 mg) described in Preparation Example 127 and 5-ethyl-3-(4-methoxybenzyl)imidazolidine-2,4-dione (176 mg) described in Preparation Example 207 and by the reaction and treatment in the same manner as in Example 508, the title compound (153 mg) was obtained via 1-{5-[4-(3,5-dimethylpyridin-2-yl)piperazine-1-carbonyl]pyridin-2-yl}-5-ethyl-3-(4-methoxybenzyl)imidazolidine-2,4-dione.

Workup

  1. customdescribed in Preparation Example 207 and by the reaction and treatment in the same manner as in Example 508

Sources & evidence

ORD record
ord-961484aaf5794fa1a4f5b875e85c9839
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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