HCID 21700179, compound → HCID 71252361, compound

HRID 2411924Notes

Reaction equation

HRID 2411924 reaction equation
BrC1N=CC(C(N2CCN(C3C(C)=CC(C)=CN=3)CC2)=O)=CC=1.COC1C=CC(CN2C(=O)C(C)(C)NC2=O)=CC=1.[CH3:42][C:43]1[C:44]([N:50]2[CH2:55][CH2:54][N:53]([C:56]([C:58]3[CH:59]=[CH:60][C:61]([N:64]4[C:68]([CH3:70])([CH3:69])[C:67](=[O:71])[N:66](CC5C=CC(OC)=CC=5)[C:65]4=[O:81])=[N:62][CH:63]=3)=[O:57])[CH2:52][CH2:51]2)=[N:45][CH:46]=[C:47]([CH3:49])[CH:48]=1>>[CH3:42][C:43]1[C:44]([N:50]2[CH2:51][CH2:52][N:53]([C:56]([C:58]3[CH:59]=[CH:60][C:61]([N:64]4[C:68]([CH3:69])([CH3:70])[C:67](=[O:71])[NH:66][C:65]4=[O:81])=[N:62][CH:63]=3)=[O:57])[CH2:54][CH2:55]2)=[N:45][CH:46]=[C:47]([CH3:49])[CH:48]=1

Participants

4

Reactant 3

HCID 21700179HCID 21700179, compoundHCID 58484661(6-Bromopyridin-3-yl)[4-(3,5-dimethylpyridin-2-yl)piperazin-1-yl]methanoneHCID 71252404HCID 71252404, compound

Product 1

HCID 71252361HCID 71252361, compound

Procedure

Using (6-bromopyridin-3-yl)[4-(3,5-dimethylpyridin-2-yl)piperazin-1-yl]methanone (225 mg) described in Preparation Example 127 and 3-(4-methoxybenzyl)-5,5-dimethylimidazolidine-2,4-dione (149 mg) described in Preparation Example 53 and by the reaction and treatment in the same manner as in Example 508, the title compound (120 mg) was obtained via 1-{5-[4-(3,5-dimethylpyridin-2-yl)piperazine-1-carbonyl]pyridin-2-yl}-3-(4-methoxybenzyl)-5,5-dimethylimidazolidine-2,4-dione.

Workup

  1. customdescribed in Preparation Example 53 and by the reaction and treatment in the same manner as in Example 508

Sources & evidence

ORD record
ord-7b6ff793068f4064a6618bb0c385924f
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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