HuagongsheHuagongshe Chemistry Print Report · For research reference only
3,5,5-Trimethylimidazolidine-2,4-dione → 1-{4-[4-(3,5-Dimethylpyridin-2-yl)piperazine-1-carbonyl]-3-fluorophenyl}-3,5,5-trimethylimidazolidine-2,4-dione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3,5,5-Trimethylimidazolidine-2,4-dione | HCID 237560 | — |
| Reactant | (4-Bromo-2-fluorophenyl)[4-(3,5-dimethylpyridin-2-yl)piperazin-1-yl]methanone | HCID 58484626 | — |
| Product | 1-{4-[4-(3,5-Dimethylpyridin-2-yl)piperazine-1-carbonyl]-3-fluorophenyl}-3,5,5-trimethylimidazolidine-2,4-dione | HCID 71252302 | 16.5% |
Reaction Steps
Using (4-bromo-2-fluorophenyl) [4-(3,5-dimethylpyridin-2-yl)piperazin-1-yl]methanone (157 mg) described in Preparation Example 114 and 3,5,5-trimethylimidazolidine-2,4-dione (63 mg) described in Preparation Example 218 and by the reaction and treatment in the same manner as in Example 536, the title compound (30 mg) was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08816079B2 |
| Source dataset | uspto-grants-2014_08 |
| ORD ID | ord-e16a136af3fc4dfa9fb755515046468f |
| Source note | uspto-grants-2014_08 |