2,4-Imidazolidinedione, 3-methyl- → HCID 71252115, compound

HRID 2411930Notes

Reaction equation

HRID 2411930 reaction equation
Br[C:2]1[N:7]=[CH:6][C:5]([C:8]([N:10]2[CH2:15][CH2:14][N:13]([C:16]3[C:21]([CH3:22])=[CH:20][C:19]([CH:23]4[CH2:25][CH2:24]4)=[CH:18][N:17]=3)[CH2:12][CH2:11]2)=[O:9])=[CH:4][CH:3]=1.[CH3:26][N:27]1[C:31](=[O:32])[CH2:30][NH:29][C:28]1=[O:33]>>[CH:23]1([C:19]2[CH:20]=[C:21]([CH3:22])[C:16]([N:13]3[CH2:14][CH2:15][N:10]([C:8]([C:5]4[CH:4]=[CH:3][C:2]([N:29]5[CH2:30][C:31](=[O:32])[N:27]([CH3:26])[C:28]5=[O:33])=[N:7][CH:6]=4)=[O:9])[CH2:11][CH2:12]3)=[N:17][CH:18]=2)[CH2:25][CH2:24]1

Participants

3

Reactant 2

HCID 1388512,4-Imidazolidinedione, 3-methyl-HCID 58484858(6-Bromopyridin-3-yl)[4-(5-cyclopropyl-3-methylpyridin-2-yl)piperazin-1-yl]methanone

Product 1

HCID 71252115HCID 71252115, compoundYield 31.6%

Procedure

Using (6-bromopyridin-3-yl)[4-(5-cyclopropyl-3-methylpyridin-2-yl)piperazin-1-yl]methanone (161 mg) described in Preparation Example 144 and 3-methylimidazolidine-2,4-dione (68 mg) described in Preparation Example 214 and by the reaction and treatment in the same manner as in Example 536, the title compound (55 mg) was obtained.

Workup

  1. customdescribed in Preparation Example 214 and by the reaction and treatment in the same manner as in Example 536

Sources & evidence

ORD record
ord-ea291f19b5904d33978632f222a39df6
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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