2,4-Imidazolidinedione, 3-methyl- → HCID 71252670, compound

HRID 2411931Notes

Reaction equation

HRID 2411931 reaction equation
Br[C:2]1[CH:7]=[CH:6][C:5]([C:8]([N:10]2[CH2:15][CH2:14][N:13]([C:16]3[C:21]([CH3:22])=[CH:20][C:19]([CH3:23])=[C:18]([CH3:24])[N:17]=3)[CH2:12][CH2:11]2)=[O:9])=[C:4]([F:25])[CH:3]=1.[CH3:26][N:27]1[C:31](=[O:32])[CH2:30][NH:29][C:28]1=[O:33]>>[F:25][C:4]1[CH:3]=[C:2]([N:29]2[CH2:30][C:31](=[O:32])[N:27]([CH3:26])[C:28]2=[O:33])[CH:7]=[CH:6][C:5]=1[C:8]([N:10]1[CH2:15][CH2:14][N:13]([C:16]2[C:21]([CH3:22])=[CH:20][C:19]([CH3:23])=[C:18]([CH3:24])[N:17]=2)[CH2:12][CH2:11]1)=[O:9]

Participants

3

Reactant 2

HCID 1388512,4-Imidazolidinedione, 3-methyl-HCID 58484847(4-Bromo-2-fluorophenyl) [4-(3,5,6-trimethylpyridin-2-yl)piperazin-1-yl]methanone

Product 1

HCID 71252670HCID 71252670, compoundYield 61.8%

Procedure

Using (4-bromo-2-fluorophenyl)[4-(3,5,6-trimethylpyridin-2-yl)piperazin-1-yl]methanone (163 mg) described in Preparation Example 128 and 3-methylimidazolidine-2,4-dione (68 mg) described in Preparation Example 214 and by the reaction and treatment in the same manner as in Example 536, the title compound (109 mg) was obtained.

Workup

  1. customdescribed in Preparation Example 214 and by the reaction and treatment in the same manner as in Example 536

Sources & evidence

ORD record
ord-c9253b0d93664da898e3c91381d45a5a
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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