2,4-Imidazolidinedione, 3-methyl- → HCID 71252383, compound

HRID 2411933Notes

Reaction equation

HRID 2411933 reaction equation
Br[C:2]1[N:7]=[CH:6][C:5]([C:8]([N:10]2[CH2:15][CH2:14][N:13]([C:16]3[C:21]([CH3:22])=[CH:20][C:19]([CH2:23][CH3:24])=[CH:18][N:17]=3)[CH2:12][CH2:11]2)=[O:9])=[CH:4][CH:3]=1.[CH3:25][N:26]1[C:30](=[O:31])[CH2:29][NH:28][C:27]1=[O:32]>>[CH2:23]([C:19]1[CH:20]=[C:21]([CH3:22])[C:16]([N:13]2[CH2:14][CH2:15][N:10]([C:8]([C:5]3[CH:4]=[CH:3][C:2]([N:28]4[CH2:29][C:30](=[O:31])[N:26]([CH3:25])[C:27]4=[O:32])=[N:7][CH:6]=3)=[O:9])[CH2:11][CH2:12]2)=[N:17][CH:18]=1)[CH3:24]

Participants

3

Reactant 2

HCID 1388512,4-Imidazolidinedione, 3-methyl-HCID 58484652(6-Bromopyridin-3-yl)[4-(5-ethyl-3-methylpyridin-2-yl)piperazin-1-yl]methanone

Product 1

HCID 71252383HCID 71252383, compoundYield 36%

Procedure

Using (6-bromopyridin-3-yl) [4-(5-ethyl-3-methylpyridin-2-yl)piperazin-1-yl]methanone (156 mg) described in Preparation Example 145 and 3-methylimidazolidine-2,4-dione (68 mg) described in Preparation Example 214 and by the reaction and treatment in the same manner as in Example 536, the title compound (61 mg) was obtained.

Workup

  1. customdescribed in Preparation Example 214 and by the reaction and treatment in the same manner as in Example 536

Sources & evidence

ORD record
ord-56bf3c4a53854ed39b00158250dfde51
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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