N-Acetylimidazolidinone → HCID 71252333, compound

HRID 2411941Notes

Reaction equation

Br[C:2]1[CH:3]=[CH:4][C:5]([C:13]([N:15]2[CH2:20][CH2:19][N:18]([C:21]3[C:26]([CH3:27])=[CH:25][C:24]([CH3:28])=[CH:23][N:22]=3)[CH2:17][CH2:16]2)=[O:14])=[C:6]([NH:8][S:9]([CH3:12])(=[O:11])=[O:10])[CH:7]=1.[C:29]([N:32]1[CH2:36][CH2:35][NH:34][C:33]1=[O:37])(=[O:31])[CH3:30]>>[C:29]([N:32]1[CH2:36][CH2:35][N:34]([C:2]2[CH:3]=[CH:4][C:5]([C:13]([N:15]3[CH2:20][CH2:19][N:18]([C:21]4[C:26]([CH3:27])=[CH:25][C:24]([CH3:28])=[CH:23][N:22]=4)[CH2:17][CH2:16]3)=[O:14])=[C:6]([NH:8][S:9]([CH3:12])(=[O:11])=[O:10])[CH:7]=2)[C:33]1=[O:37])(=[O:31])[CH3:30]

Participants

Reactant 2

HCID 79350N-Acetylimidazolidinone

HCID 58484868N-{5-bromo-2-[4-(3,5-dimethylpyridin-2-yl)piperazine-1-carbonyl]phenyl}methanesulfonamide

Product 1

HCID 71252333HCID 71252333, compoundYield 13%

Procedure

Using N-{5-bromo-2-[4-(3,5-dimethylpyridin-2-yl)piperazine-1-carbonyl]phenyl}methanesulfonamide (806 mg) described in Preparation Example 226 and 1-acetylimidazolidin-2-one (221 mg) and by the reaction and treatment in the same manner as in Example 536, the title compound (115 mg) was obtained.

Sources & evidence

ORD record: ord-63f5be74071647fa8a44c7e4a6f8ca68
Source dataset: uspto-grants-2014_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08816079B2

Reaction notes

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