Methyl iodide → HCID 71252914, compound

HRID 2411942Notes

Reaction equation

[C:1]([N:4]1[CH2:8][CH2:7][N:6]([C:9]2[CH:10]=[CH:11][C:12]([C:20]([N:22]3[CH2:27][CH2:26][N:25]([C:28]4[C:33]([CH3:34])=[CH:32][C:31]([CH3:35])=[CH:30][N:29]=4)[CH2:24][CH2:23]3)=[O:21])=[C:13]([NH:15][S:16]([CH3:19])(=[O:18])=[O:17])[CH:14]=2)[C:5]1=[O:36])(=[O:3])[CH3:2].[CH3:37]I>>[C:1]([N:4]1[CH2:8][CH2:7][N:6]([C:9]2[CH:10]=[CH:11][C:12]([C:20]([N:22]3[CH2:23][CH2:24][N:25]([C:28]4[C:33]([CH3:34])=[CH:32][C:31]([CH3:35])=[CH:30][N:29]=4)[CH2:26][CH2:27]3)=[O:21])=[C:13]([N:15]([CH3:37])[S:16]([CH3:19])(=[O:18])=[O:17])[CH:14]=2)[C:5]1=[O:36])(=[O:3])[CH3:2]

Participants

Reactant 2

HCID 6328Methyl iodide

HCID 71252333HCID 71252333, compound

Product 1

HCID 71252914HCID 71252914, compound

Procedure

Using N-{5-(3-acetyl-2-oxoimidazolidin-1-yl)-2-[4-(3,5-dimethylpyridin-2-yl)piperazine-1-carbonyl]phenyl}methanesulfonamide (93 mg) described in Example 596 and methyl iodide (12.3 μL) and by the reaction and treatment in the same manner as in Example 36, the title compound (15 mg) was obtained.

Sources & evidence

ORD record: ord-ccdaffd873784d08b468f88cd2c1eed6
Source dataset: uspto-grants-2014_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08816079B2

Reaction notes

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