1-Methylimidazolidin-2-one → HCID 71252833, compound

HRID 2411943Notes

Reaction equation

HRID 2411943 reaction equation
Br[C:2]1[CH:3]=[CH:4][C:5]([C:13]([N:15]2[CH2:20][CH2:19][N:18]([C:21]3[C:26]([CH3:27])=[CH:25][C:24]([CH3:28])=[CH:23][N:22]=3)[CH2:17][CH2:16]2)=[O:14])=[C:6]([NH:8][S:9]([CH3:12])(=[O:11])=[O:10])[CH:7]=1.[CH3:29][N:30]1[CH2:34][CH2:33][NH:32][C:31]1=[O:35]>>[CH3:27][C:26]1[C:21]([N:18]2[CH2:19][CH2:20][N:15]([C:13]([C:5]3[CH:4]=[CH:3][C:2]([N:32]4[CH2:33][CH2:34][N:30]([CH3:29])[C:31]4=[O:35])=[CH:7][C:6]=3[NH:8][S:9]([CH3:12])(=[O:11])=[O:10])=[O:14])[CH2:16][CH2:17]2)=[N:22][CH:23]=[C:24]([CH3:28])[CH:25]=1

Participants

3

Reactant 2

HCID 5676001-Methylimidazolidin-2-oneHCID 58484868N-{5-bromo-2-[4-(3,5-dimethylpyridin-2-yl)piperazine-1-carbonyl]phenyl}methanesulfonamide

Product 1

HCID 71252833HCID 71252833, compoundYield 26.7%

Procedure

Using N-{5-bromo-2-[4-(3,5-dimethylpyridin-2-yl)piperazine-1-carbonyl]phenyl}methanesulfonamide (187 mg) described in Preparation Example 226 and 1-methylimidazolidin-2-one (40 mg) and by the reaction and treatment in the same manner as in Example 536, the title compound (52 mg) was obtained.

Sources & evidence

ORD record
ord-11d54a9cf5004442a37171f74e1749df
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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