HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Methylimidazolidin-2-one → N-{2-[4-(3,5-dimethylpyridin-2-yl)piperazine-1-carbonyl]-5-(3-methyl-2-oxoimidazolidin-1-yl)phenyl}-N-methylmethanesulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Methylimidazolidin-2-one | HCID 567600 | — |
| Reactant | N-{5-bromo-2-[4-(3,5-dimethylpyridin-2-yl)piperazine-1-carbonyl]phenyl}-N-methylmethanesulfonamide | HCID 71252240 | — |
| Product | N-{2-[4-(3,5-dimethylpyridin-2-yl)piperazine-1-carbonyl]-5-(3-methyl-2-oxoimidazolidin-1-yl)phenyl}-N-methylmethanesulfonamide | HCID 71252729 | 70.4% |
Reaction Steps
Using N-{5-bromo-2-[4-(3,5-dimethylpyridin-2-yl)piperazine-1-carbonyl]phenyl}-N-methylmethanesulfonamide (130 mg) described in Preparation Example 227 and 1-methylimidazolidin-2-one (27 mg) and by the reaction and treatment in the same manner as in Example 536, the title compound (95 mg) was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08816079B2 |
| Source dataset | uspto-grants-2014_08 |
| ORD ID | ord-17a34ebd8af64a8d89645ddcf0ae2261 |
| Source note | uspto-grants-2014_08 |