1-Methylimidazolidin-2-one → HCID 71252413, compound

HRID 2411954Notes

Reaction equation

HRID 2411954 reaction equation
Br[C:2]1[CH:7]=[CH:6][C:5]([C:8]([N:10]2[CH2:15][CH2:14][N:13]([C:16]3[C:21]([CH3:22])=[CH:20][C:19]([CH3:23])=[C:18]([CH3:24])[N:17]=3)[CH2:12][CH2:11]2)=[O:9])=[C:4]([F:25])[CH:3]=1.[CH3:26][N:27]1[CH2:31][CH2:30][NH:29][C:28]1=[O:32]>>[F:25][C:4]1[CH:3]=[C:2]([N:29]2[CH2:30][CH2:31][N:27]([CH3:26])[C:28]2=[O:32])[CH:7]=[CH:6][C:5]=1[C:8]([N:10]1[CH2:15][CH2:14][N:13]([C:16]2[C:21]([CH3:22])=[CH:20][C:19]([CH3:23])=[C:18]([CH3:24])[N:17]=2)[CH2:12][CH2:11]1)=[O:9]

Participants

3

Reactant 2

HCID 5676001-Methylimidazolidin-2-oneHCID 58484847(4-Bromo-2-fluorophenyl) [4-(3,5,6-trimethylpyridin-2-yl)piperazin-1-yl]methanone

Product 1

HCID 71252413HCID 71252413, compoundYield 8%

Procedure

Using (4-bromo-2-fluorophenyl)[4-(3,5,6-trimethylpyridin-2-yl)piperazin-1-yl]methanone (203 mg) described in Preparation Example 128 and 1-methylimidazolidin-2-one (60 mg) and by the reaction and treatment in the same manner as in Example 511, the title compound (17 mg) was obtained.

Sources & evidence

ORD record
ord-cfe45fbe8fc143f1a1ac524a478ce6cd
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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