1-Methylimidazolidin-2-one → HCID 71252549, compound

HRID 2411960Notes

Reaction equation

HRID 2411960 reaction equation
Br[C:2]1[CH:3]=[N:4][C:5]([C:8]([N:10]2[CH2:15][CH2:14][N:13]([C:16]3[C:21]([CH3:22])=[CH:20][C:19]([CH3:23])=[CH:18][N:17]=3)[CH2:12][CH2:11]2)=[O:9])=[N:6][CH:7]=1.[CH3:24][N:25]1[CH2:29][CH2:28][NH:27][C:26]1=[O:30]>>[CH3:22][C:21]1[C:16]([N:13]2[CH2:14][CH2:15][N:10]([C:8]([C:5]3[N:4]=[CH:3][C:2]([N:27]4[CH2:28][CH2:29][N:25]([CH3:24])[C:26]4=[O:30])=[CH:7][N:6]=3)=[O:9])[CH2:11][CH2:12]2)=[N:17][CH:18]=[C:19]([CH3:23])[CH:20]=1

Participants

3

Reactant 2

HCID 5676001-Methylimidazolidin-2-oneHCID 71252096HCID 71252096, compound

Product 1

HCID 71252549HCID 71252549, compoundYield 40.5%

Procedure

Using (5-bromopyrimidin-2-yl)[4-(3,5-dimethylpyridin-2-yl)piperazin-1-yl]methanone (188 mg) described in Preparation Example 229 and 1-methylimidazolidin-2-one (50 mg) and by the reaction and treatment in the same manner as in Example 536, the title compound (80 mg) was obtained.

Sources & evidence

ORD record
ord-49a81d370be24e3688b5373ed69f43e3
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

Loading…