1lambda~6~,2-Thiazetidine-1,1-dione → HCID 71252733, compound

HRID 2411963Notes

Reaction equation

HRID 2411963 reaction equation
[CH3:1][C:2]1[CH:7]=[C:6]([CH3:8])[CH:5]=[CH:4][C:3]=1[N:9]1[CH2:14][CH2:13][N:12]([C:15]([C:17]2[CH:22]=[CH:21][C:20](I)=[CH:19][CH:18]=2)=[O:16])[CH2:11][CH2:10]1.[S:24]1(=[O:29])(=[O:28])[CH2:27][CH2:26][NH:25]1>>[CH3:1][C:2]1[CH:7]=[C:6]([CH3:8])[CH:5]=[CH:4][C:3]=1[N:9]1[CH2:14][CH2:13][N:12]([C:15]([C:17]2[CH:22]=[CH:21][C:20]([N:25]3[CH2:26][CH2:27][S:24]3(=[O:29])=[O:28])=[CH:19][CH:18]=2)=[O:16])[CH2:11][CH2:10]1

Participants

3

Reactant 2

HCID 129590531lambda~6~,2-Thiazetidine-1,1-dioneHCID 58484733[4-(2,4-Dimethylphenyl)piperazin-1-yl](4-iodophenyl)methanone

Product 1

HCID 71252733HCID 71252733, compoundYield 7.5%

Procedure

Using [4-(2,4-dimethylphenyl)piperazin-1-yl](4-iodophenyl)methanone (210 mg) described in Preparation Example 108 and [1,2]thiazetidine 1,1-dioxide (54 mg) and by the reaction and treatment in the same manner as in Example 536, the title compound (15 mg) was obtained.

Sources & evidence

ORD record
ord-78aac25f84d04d47a07b72d592a0e86c
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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