1-(3,5-Dimethylpyridin-2-yl)piperazine → HCID 71252571, compound

HRID 2411965Notes

Reaction equation

HRID 2411965 reaction equation
[O:1]=[S:2]1(=[O:17])[CH2:6][CH2:5][CH2:4][N:3]1[C:7]1[N:12]=[CH:11][C:10]([C:13]([O:15]C)=O)=[CH:9][N:8]=1.[CH3:18][C:19]1[C:20]([N:26]2[CH2:31][CH2:30][NH:29][CH2:28][CH2:27]2)=[N:21][CH:22]=[C:23]([CH3:25])[CH:24]=1>>[CH3:18][C:19]1[C:20]([N:26]2[CH2:27][CH2:28][N:29]([C:13]([C:10]3[CH:11]=[N:12][C:7]([N:3]4[CH2:4][CH2:5][CH2:6][S:2]4(=[O:1])=[O:17])=[N:8][CH:9]=3)=[O:15])[CH2:30][CH2:31]2)=[N:21][CH:22]=[C:23]([CH3:25])[CH:24]=1

Participants

3

Reactant 2

HCID 584844961-(3,5-Dimethylpyridin-2-yl)piperazineHCID 71252464HCID 71252464, compound

Product 1

HCID 71252571HCID 71252571, compoundYield 17.4%

Procedure

Using methyl 2-(1,1-dioxo-1λ6-isothiazolidin-2-yl)pyrimidine-5-carboxylate (100 mg) described in Preparation Example 231 and 1-(3,5-dimethylpyridin-2-yl)piperazine (74 mg) described in Preparation Example 79 and by the reaction and treatment in the same manner as in Example 109, the title compound (28 mg) was obtained.

Workup

  1. customdescribed in Preparation Example 79 and by the reaction and treatment in the same manner as in Example 109

Sources & evidence

ORD record
ord-79c8c91a2cef4fa68f123b985ea89a86
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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