1-(5-Cyclopropyl-3-methylpyridin-2-yl)piperazine → HCID 71252357, compound

HRID 2411966Notes

Reaction equation

HRID 2411966 reaction equation
[O:1]=[S:2]1(=[O:17])[CH2:6][CH2:5][CH2:4][N:3]1[C:7]1[N:12]=[CH:11][C:10]([C:13]([O:15]C)=O)=[CH:9][N:8]=1.[CH:18]1([C:21]2[CH:22]=[C:23]([CH3:33])[C:24]([N:27]3[CH2:32][CH2:31][NH:30][CH2:29][CH2:28]3)=[N:25][CH:26]=2)[CH2:20][CH2:19]1>>[CH:18]1([C:21]2[CH:22]=[C:23]([CH3:33])[C:24]([N:27]3[CH2:28][CH2:29][N:30]([C:13]([C:10]4[CH:11]=[N:12][C:7]([N:3]5[CH2:4][CH2:5][CH2:6][S:2]5(=[O:1])=[O:17])=[N:8][CH:9]=4)=[O:15])[CH2:31][CH2:32]3)=[N:25][CH:26]=2)[CH2:20][CH2:19]1

Participants

3

Reactant 2

HCID 584847181-(5-Cyclopropyl-3-methylpyridin-2-yl)piperazineHCID 71252464HCID 71252464, compound

Product 1

HCID 71252357HCID 71252357, compoundYield 6.8%

Procedure

Using methyl 2-(1,1-dioxo-1λ6-isothiazolidin-2-yl)pyrimidine-5-carboxylate (85 mg) described in Preparation Example 231 and 1-(5-cyclopropyl-3-methylpyridin-2-yl)piperazine (72 mg) described in Preparation Example 83 and by the reaction and treatment in the same manner as in Example 109, the title compound (10 mg) was obtained.

Workup

  1. customdescribed in Preparation Example 83 and by the reaction and treatment in the same manner as in Example 109

Sources & evidence

ORD record
ord-1b4644125d8e412598526398fdf0d2e1
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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