1,3-Propanesultam → HCID 71252149, compound

HRID 2411968Notes

Reaction equation

HRID 2411968 reaction equation
Br[C:2]1[N:3]=[CH:4][C:5]([C:8]([N:10]2[CH2:15][CH2:14][N:13]([C:16]3[C:21]([CH3:22])=[CH:20][C:19]([CH3:23])=[CH:18][N:17]=3)[CH2:12][CH2:11]2)=[O:9])=[N:6][CH:7]=1.[S:24]1(=[O:30])(=[O:29])[CH2:28][CH2:27][CH2:26][NH:25]1>>[CH3:22][C:21]1[C:16]([N:13]2[CH2:14][CH2:15][N:10]([C:8]([C:5]3[CH:4]=[N:3][C:2]([N:25]4[CH2:26][CH2:27][CH2:28][S:24]4(=[O:30])=[O:29])=[CH:7][N:6]=3)=[O:9])[CH2:11][CH2:12]2)=[N:17][CH:18]=[C:19]([CH3:23])[CH:20]=1

Participants

3

Reactant 2

HCID 6421571,3-PropanesultamHCID 86676767HCID 86676767, compound

Product 1

HCID 71252149HCID 71252149, compoundYield 51.6%

Procedure

Using (5-bromopyrazin-2-yl)[4-(3,5-dimethylpyridin-2-yl)piperazin-1-yl]methanone (49 mg) described in Preparation Example 232 and isothiazolidine 1,1-dioxide (16 mg) and by the reaction and treatment in the same manner as in Example 1, the title compound (28 mg) was obtained.

Sources & evidence

ORD record
ord-a128b61e81164356afd11e3712352312
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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