1-Methylimidazolidin-2-one → HCID 71252321, compound

HRID 2411970Notes

Reaction equation

HRID 2411970 reaction equation
Br[C:2]1[N:3]=[CH:4][C:5]([C:8]([N:10]2[CH2:15][CH2:14][N:13]([C:16]3[C:21]([CH3:22])=[CH:20][C:19]([CH3:23])=[CH:18][N:17]=3)[CH2:12][CH2:11]2)=[O:9])=[N:6][CH:7]=1.[CH3:24][N:25]1[CH2:29][CH2:28][NH:27][C:26]1=[O:30]>>[CH3:22][C:21]1[C:16]([N:13]2[CH2:14][CH2:15][N:10]([C:8]([C:5]3[N:6]=[CH:7][C:2]([N:27]4[CH2:28][CH2:29][N:25]([CH3:24])[C:26]4=[O:30])=[N:3][CH:4]=3)=[O:9])[CH2:11][CH2:12]2)=[N:17][CH:18]=[C:19]([CH3:23])[CH:20]=1

Participants

3

Reactant 2

HCID 5676001-Methylimidazolidin-2-oneHCID 86676767HCID 86676767, compound

Product 1

HCID 71252321HCID 71252321, compoundYield 61.8%

Procedure

Using (5-bromopyrazin-2-yl)[4-(3,5-dimethylpyridin-2-yl)piperazin-1-yl]methanone (188 mg) described in Preparation Example 232 and 1-methylimidazolidin-2-one (50 mg) and by the reaction and treatment in the same manner as in Example 536, the title compound (122 mg) was obtained.

Sources & evidence

ORD record
ord-6d5e594a250343eeb8c9821347b96c29
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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